The ancient harbor city of Priene probably changed its location when the silt of the Meander River threatened to bury it. Now it is nearly 16 km / 10 mi from the sea. The original place of the city has never been found but it was probably a peninsula with two harbors. Priene was laid out on a Hippodamian system of grid plan at the foot of a spectacular cliff on Mount Mycale and contained many famous examples of Hellenistic art and architecture. All the streets intersect at right angles. Remaining small with about 4 or 5 thousand inhabitants and never of great political significance it shared the same history as the other Ionian cities.

Miletus an ancient city located near the present Akkoy at the mouth of the Buyuk Menderes (Meander) River, owed its importance to its position on trade routes. It was one of the largest cities in Anatolia with a population of between 80,000 and 100,000. Highly prosperous, it founded many colonies and was the home of the 6C BC philosophers Anaximander, Anaximenes, and Thales, the town planner Hippodamus and architect Isidorus. Miletus seems to have produced geniuses the way Aphrodisias produced sculptors.

The word Didyma meant twins and was associated by some as being the meeting place of Zeus and Leto to have their twins Apollo and Artemis.Didyma was famed as a prophecy center dedicated to Apollo which served a similar purpose as the Delphi of Anatolia. It was not a city but a sanctuary linked to Miletus by Milesians with a 19 km / 12 mi sacred road. However, this road may not have been constructed until the end of the 1C AD. In addition to pilgrimages made by sea, some festivals of drama, music and sports were held there every four years.